Friday, October 25, 2013

LG Optimus F6 (T-Mobile)


LG's Optimus F6 ($49.99 up front and $10/month for 24 months or $289.99) has some of the looks of a higher-end phone—the disco-ball reflective pattern on the back evokes LG's Nexus 4, and the brushed-metal highlights on the side are a classy touch. But this Android phone has the performance, storage and capabilities of an older, less-expensive device. You can do better for less on T-Mobile.



Size, Screen, And Storage
At 5.03 by 2.59 by .4 inches (HWD), the 4.44-ounce Optimus F6 is not as wide as many new smartphones—a good thing if you value single-handed use—and barely chunkier. A large physical Home/Power button helps avoid the embarrassment of extracting the phone from your pocket upside-down.



The F6's 4.5-inch, 960-by-540-pixel display can feel more crowded than that size would suggest, however. Credit a joint effort by LG and T-Mobile to clutter the notification menu: The usual strip of wireless-control widgets, LG's "QSlide apps" list, a brightness control, and a T-Mobile widget counting how many voice minutes and text messages you've used all combine to eat up more than half the screen. The last is particularly dumb, since T-Mobile's plans all come with unmetered voice and text usage. Disable it in the T-Mobile My Account App by pressing the menu button and selecting Options.


Yes, Menu button—LG replaced the standard Recent-Apps button with one for the menu function Google has been trying to kick to the curb since Android 3.0. This means you can't invoke Google Now with a simple upward swipe; instead, you must press and hold the Home button to bring up the recent-apps list, then tap the "G" button.


You can pry off the back to expose a removable 2,460mAh battery, micro SIM slot, and microSD card slot. Filling the latter should be your first priority, as the F6 ships with an advertised 4GB of storage but offers only 1.1GB for use out of the box. That's borderline cruel, and also a silly way to save a few bucks—phone vendors routinely hand out press kits on giveaway 4GB flash drives.


Calls, Battery Life, and Bandwidth
Voice quality is a mixed bag. Incoming calls sounded fine, but my own voice sounded just a bit muddy—more so via the microphone than in speakerphone mode—in voicemails left from the F6. Whispers didn't come through at all; other phones I've tried haven't had that issue. Noise cancellation suppressed all but the higher notes of a whirring engine, although the resulting background whine wasn't too fun to listen to.


Like some other Android phones I've tested, the F6 had a hang-up with Bluetooth voice dialing: When I spoke a contact's name through a Plantronics hands-free kit, the phone heard me clearly. But it repeatedly heard phone numbers as unrelated people's names.


I cannot, however, complain much about battery life here. It lasted for 15 hours and 3 minutes of talk time. That's not as good as T-Mobile's estimate of 19.5 hours but still far better than average. After being left idle for 24 hours, the F6 showed 91 percent charge left; that's also great.


The F6 connected to T-Mobile's LTE network with excellent results—the Speedtest.net app clocked a stellar download speed of 47.01 Mbps in Santa Clara, Calif., with an upload speed of 9.5 Mbps. As a backup to that, you've got T-Mobile's also speedy HSPA+ and the option to connect to WiFi's a, b, g, and n flavors, 5GHz networks included.


Camera, Connectivity, and Apps
The most obviously cut corner here after the inadequate storage would be the mediocre 5-megapixel back camera. Its still images exhibited problems with focusing and cast a gauzy glow around bright or backlit objects that made me think "2009 camera phone."


The front camera, with only 1.3 MP of resolution, has the same problems. And videos from either side looked even worse, maxing out at about 20 frames per second in indoor shots. The back camera's touted 1080p resolution seemed too much for its older, slower processor to properly encode, judging by the blurring that wasn't such a problem in the front camera's 720p video.


The long and often redundant list of add-on apps—once again, an Android vendor has seen fit to install both Google's Chrome and a lesser browser, then throw in task-manager and file-manager utilities that most Android users don't need—hides a few interesting surprises. A QuickRemote app can turn the phone into a remote for a TV or a cable box, although it failed to recognize a 2009-vintage Sony HDTV, and an LG Backup app can save your apps and settings to a microSD card.


The LG Gallery app played a QuickTime movie, something stock Android can't do. And under the Display category of LG's version of the Settings app, you can also enable "Smart Screen," which keeps the screen lit if the phone sees your eyes focused on it. You may also want to jump into the "Language & Input" category to disable the distracting "blam-blam" noises made by the LG keyboard's haptic feedback.


This thing is also on the sluggish side—it benchmarked not much faster than the 2011-vintage Galaxy S II—and needless visual effects like the way app icons and widgets bounce into view as you shuffle from home screen to another add to the lag factor.


Conclusions
An unsubsidized price of less than $300 is hard to ignore, but T-Mobile has better cheap choices. For instance, if you can do without a front camera, LG's own Optimus F3 is $50 cheaper and a good deal more compact, while the $120 Nokia Lumia 521 offers a cleaner Windows Phone interface free of aftermarket trimmings, albeit with a considerably smaller selection of apps.


Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/LmddTEb9bNo/0,2817,2426301,00.asp
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Polaroid Toilet Paper Holder Captures Memories You Don't Want To Keep

Polaroid Toilet Paper Holder Captures Memories You Don't Want To Keep

Even though digital cameras provide us the same instant gratification after snapping a photo, Polaroid's instant snapper still has a cult following. Of course, that also means that instant film is more expensive than ever, so if you're just a fan of the Polaroid camera's iconic design, this Pola Roll toilet paper holder is a cheaper way to keep one around for posterity.

Read more...


    






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Katharine McPhee Affair May Have Ended 2 Marriages

Smash was cancelled this spring, but the drama continues for Katharine McPhee! The star of the musical drama, who is married to producer Nick Cokas, was caught by paparazzi on Sunday kissing former Smash director Michael Morris. Morris is also married, to actress Mary McCormack. As you can imagine, this is getting messy.
Source: http://www.ivillage.com/katharine-mcphee-caught-kissing-married-director-michael-morris/1-a-550777?dst=iv%3AiVillage%3Akatharine-mcphee-caught-kissing-married-director-michael-morris-550777
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Row Over Stilton Could Cause A Stink


The British government has told a pub in the village of Stilton that it can't call its cheese Stilton. The name is protected by a law that says true Stilton cheese can come from three specific regions — not Cambridgeshire, where Stilton is located. The pub's landlord is weighing his legal options.


Source: http://www.npr.org/2013/10/25/240692890/row-over-stilton-could-cause-a-stink?ft=1&f=3
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Hong Kong Directors Guild Boss Calls 'Transformers 4' Incident 'Ridiculous'


Hong Kong police are holding a suspected Triad gang member on suspicion of attempting to extort money from the crew on the set of Transformers: Age of Extinction, the second attempt in five days to blackmail the Paramount Pictures crew during filming in Hong Kong.



Hong Kong Directors Guild president Derek Yee Tung-sing told the South China Morning Post newspaper that the incident was "ridiculous" and "more unusual than getting a jackpot."


PHOTOS: Power Lawyers: 'Star Trek's' JJ Abrams, Michael Bay and Les Moonves Pose With Their Attorneys


On Thursday (Oct. 17) last week, the director of the fourth installment in the franchise, Michael Bay, and several crewmembers escaped injury after they were assaulted by a man wielding an air-conditioning unit as a weapon. Two brothers were arrested after allegedly demanding $13,000 (HK$100,000) from the crew.


Hong Kong is a famously safe city and there have been no cases of blackmail or extortion on film crews in recent years since a major crackdown on the organized crime tactic decades ago, although in some film productions, security sources say that unofficial "protection money" payments are made.


Police are looking for three alleged racketeers in connection with the latest case, which happened on the roof of a residential block in To Kwa Wan Road in the city at about 2.30 p.m. on Tuesday (Oct. 22), the newspaper reported.


According to police, the four men allegedly approached and demanded money from the crew, who were assessing the site at the time. The crew immediately called police.


STORY: Michael Bay Attacked on 'Transformers 4' Set in Hong Kong


Officers arrested a 35-year-old Hong Kong man but the other three men escaped. A police source said the man was a suspected Triad criminal gang member.


The producers have worked hard to push the movie as a China-U.S. co-production, thereby allowing it to sidestep the Chinese import quota and also take a bigger share of box office earnings in what is now the second-biggest source of box office revenue in the world.


The 2011 smash hit Transformers: Dark of the Moon took $165 million of its $1.1 billion worldwide take in China.


Transformers: Age of Extinction stars Mark Wahlberg, Nicola Peltz, Jack Reynor, Li Bingbing and Han Geng and is due in theaters on June 27, 2014.


Four young Chinese actors were chosen to play supporting roles in Transformers: Age of Extinction in a reality TV show aired on state broadcaster CCTV's Movie Channel on Aug. 31.


Source: http://feedproxy.google.com/~r/thr/news/~3/ig6hoaVW32U/hong-kong-transformers-4-attack-650836
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Pen Pal Of Young 'Jerry' Salinger May Have Been First To Meet Holden





J.D. Salinger wrote nine letters and postcards to aspiring Canadian writer Marjorie Sheard.



Graham Haber/The Morgan Library & Museum


J.D. Salinger wrote nine letters and postcards to aspiring Canadian writer Marjorie Sheard.


Graham Haber/The Morgan Library & Museum


Fans of the reclusive J.D. Salinger are in their element these days. The writer, who died in 2010, is the subject of a recent documentary and companion biography; there's word that five Salinger works will be published for the first time, starting in 2015; and now, the Morgan Library in New York is showing never-before displayed letters that a 20-something Salinger wrote, from 1941 to 1943, to a young admirer in Toronto.


For Salinger buffs, this is like a glimpse of the holy grail: seven letters and two postcards, mostly typed, two handwritten. Salinger's handwriting is slanted and spiky.


"He's writing quickly. He may have been writing this in a bar," says curator Declan Kiely. "The thing that jumps out at me is the way he forms 'I.' "


In a sea of cursives, Salinger prints his "I" — it looks like the Roman numeral one. He makes a strong vertical line and two horizontals.





Salinger, shown here in September 1961, comes off as both diffident and confident in his letters to Sheard.



AP


Salinger, shown here in September 1961, comes off as both diffident and confident in his letters to Sheard.


AP


"They're really emphatic," Kiely says.


And he underlines his name — sometimes with one line, sometimes two.


"You see Dickens doing this, you see Edgar Allen Poe doing this," observes Kiely, who is head of the Department of Literary and Historical Manuscripts at the Morgan Library. "A lot of male writers have what I would call a sort of architectural support."


Salinger Before Catcher in the Rye


Salinger's first letter to Marjorie Sheard is dated Sept. 4, 1941.


"Dear Miss Sheard," he writes. "Your warm, bright letter just reached me. Thanks very much. It's unfair to authors that you write only to Aldous Huxley and me."


Sheard had written to praise stories of Salinger's that she'd seen in Esquire and Collier's magazines. Like Salinger, she was in her early 20s and wanted to write fiction. He gives her advice: "Why don't you try writing something for Mademoiselle or one of the other feminine magazines? Seems to me you have the instincts to avoid the usual Vassar-girl tripe those mags publish."


He put his parents' address (1133 Park Ave., on 91st Street in Manhattan) in the upper right corner. He has typed the letter neatly — no cross-outs or erasures.


"He would have made a great secretary," Kiely says, smilingly.


Salinger, clearly thrilled to get a fan letter this early in his writing career, ends his note this way: "I hope you'll always read my work with pleasure. So glad you liked the Esquire piece. I write for Marjorie Sheard and a few others. The fact that Esquire's circulation is 600,000, and Collier's is in millions is purely coincidental."


Kiely thinks these letters reveal who Salinger was before Catcher in the Rye made him a literary star.


"He's a combination of diffidence and confidence," he says. "He is right at the very beginning, but he knows that he's onto something."


He's also witty. Later in their correspondence, after Salinger has been drafted and is waiting to be shipped overseas from Army basic training in Georgia, this Upper East Side prep school fellow writes, "Can't you just picture me leading me little platoon over the top? You boys go ahead. I'll meet you at the Biltmore under the clock."


An Early Hint At Holden


And who was she, Miss Marjorie Sheard of Toronto? Only one of her letters to him survives. In a P.P.S. she provides some "vital statistics" — a list of her likes: "Drinking beer, also rum; Sunday afternoon cocktail parties; flirting; dancing in a too-high, too-crowded place; white evening gowns; men who are tall, dark and dangerous; writing letters to Jerry Salinger. My father's a lawyer who plays the cello and writes musical criticisms. My mother is extremely beautiful. My brother is crotchety and practical, but I like him."





Marjorie Sheard was only slightly older than Salinger. Only one of her letters to him survives.



The Morgan Library & Museum, Gift of Marjorie Sheard Carter


Marjorie Sheard was only slightly older than Salinger. Only one of her letters to him survives.


The Morgan Library & Museum, Gift of Marjorie Sheard Carter


Sheard was slightly older than Salinger. (His correspondence with teenage girls would come later). Her niece, Sarah Sheard, says Marjorie was quiet and shy. But she had a real writer's voice in that flirtatious P.P.S. A month after his first letter, Salinger is getting curious.


"Dear Marjorie," he writes. "Excuse the delay but I've been up to here and still am. Thanks for writing. What do you look like? Send a huge photo."


She does. In profile, the photograph reveals a nice straight nose and wavy dark hair that flows down her back.


On Nov. 18, 1941, Salinger writes, "Sneaky girl. You're pretty." That same letter also has news: After many rejections, The New Yorker magazine has accepted one of his stories. He tells her it's about a prep school kid on Christmas vacation.


"Let me know what you think of the first Holden story, called 'Slight Rebellion Off Madison,' " he writes. "Best, Jerry S."


Curator Declan Kiely says that November 1941 letter may be the most valuable in this collection.


"It could well be that Marjorie Sheard was one of the first people who learned of the creation of the character Holden Caulfield," he says.



The story was scheduled to run Christmas week, 1941. But it would be another five years before readers actually met Holden, the character who became the hero of Catcher in the Rye and one of the most beloved figures in fiction. The Japanese attacked Pearl Harbor a month after Jerry wrote Marjorie about the New Yorker acceptance. Editors decided, given the circumstances, that the "Holden story" was "unpublishable."


A Coquettish Correspondent


Sarah Sheard says her aunt Marjorie never talked about her pen pal and mentor.


"She was a little coquettish about it," Sheard says. "She would sort of bat her eyes and say, 'Well, you know, I did have this brief, you know, exchange with J.D. Salinger.' Jerry Salinger, she called him."


She saved all the letters, and agreed the family could sell them to pay for the Toronto nursing home where she died last May, just before her 95th birthday.


Marjorie Sheard never published any fiction, but she did have a 30-year career writing advertising. Her young 1940s correspondent became one of the world's best-known authors.


Source: http://www.npr.org/2013/10/22/239864193/pen-pal-of-young-jerry-salinger-may-have-been-first-to-meet-holden?ft=1&f=3
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Rubinius seeks to modernize, not bury, the Ruby language



All appearances of condemnation aside, proponents of the Rubiniux X project are embarking on an effort to modernize the Ruby language, bringing it into the Internet era and focusing on improved concurrency.


A glance at the recent formal announcement of Rubinius X could give the impression it was written by a Ruby antagonist, as it belittles the language, saying, "Ruby is a dying language. Business is over its dalliance with Ruby. No major startup is lauding their use of Ruby, and existing businesses are migrating away or simply writing new applications in a different language."


But the engineer who unveiled Rubinius X, Brian Shirai, of Engine Yard, emphasized he is an advocate, not an opponent: "I love Ruby. I think it's a fantastic language."


Ruby, he said, is more accessible than newer languages like Scala, but it needs to be brought into the networked, Internet era. "The motivating idea behind Rubinius X today is that there are no computers that do anything interesting without talking to at least one other computer. The Internet is forever." But Ruby's core library was built back in the Windows 3.0 days in the 1990s, before Internet dominance, Shirai added. Rubinius X is focused on the writing of collaborative, concurrent applications.


Recently, Ruby founder Yukihiro Matsumoto said he saw no need for major improvements to Ruby in his CRuby implementation, but Rubinius X advocates will continue overhauling the language anyway. Rubinius X builds on Rubinius, an implementation of Ruby that also stressed concurrency via native threads, but version 10 takes concurrency a step further. "More than any specific feature in Rubinius X, it is that the entire system is being reworked from the bottom up to support the highest degree of concurrency and parallelism possible," Shirai said. "Certain APIs are being changed, further concurrency abstractions are being added, and all of this is built-in, instead of being an afterthought relegated to the 'standard library' or other libraries."


Key features of Rubinius X for concurrency include promises and nonblocking I/O. "Promises are a more modern mechanism for concurrency," Shirai said. Promises refer to constructs used for synchronizing in some languages, in which an object acts a proxy for result that is initially unknown, often because the computation of its value is not yet complete.


Version X also is slated to include persistent and concurrent data structures, as well as mirrors and object capabilities. Mirrors are a construct providing structure for composition through encapsulation and separation of object and meta-data object operations, according to Rubiniux X advocates; object capabilities structure interactions to control collaboration. Code-loading in Rubinius X, meanwhile, enables the combining of components into a single, running program.


Matsumoto gave an endorsement to Rubinius X, despite the criticism heaped on Ruby itself. "I am a true believer of diversity," he said. "So I consider Rubinius itself diversity." But Matsumoto said he was not sure Rubinius would survive. Still, he expects it to enrich the Ruby ecosystem.


"[Shirai] claimed 'Ruby is a dying language,' but as long as Ruby continues evolving, [including Rubinius], I think it will keep growing."


This story, "Rubinius seeks to modernize, not bury, the Ruby language," was originally published at InfoWorld.com. Get the first word on what the important tech news really means with the InfoWorld Tech Watch blog. For the latest developments in business technology news, follow InfoWorld.com on Twitter.


Source: http://www.infoworld.com/t/ruby-rails/rubinius-seeks-modernize-not-bury-the-ruby-language-229445?source=rss_infoworld_blogs
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Madagascar holds first post-coup vote


ANTANANARIVO, Madagascar (AP) — Residents of the island nation of Madagascar voted Friday in a presidential election they hope will restore security, improve lives and mark the end of political and economic turmoil brought about by a 2009 coup.

Voter turnout increased by the afternoon after a slow start in the morning as residents chose to go to work instead of the polls. At the start of the vote, only 50 voters in line at a public junior school on the outskirts of Antananarivo, the capital.

Emilienne Ravaonasolo, 65, said she hoped the vote would help better the lives of the people in Madagascar.

"Hopefully the person I vote for will have the experience to restore security and improve the lives of the people," she said.

United Nations officials said polling was "going well."

Fatma Samoura, a representative of the U.N. Development Program in Madagascar said "People are calm, they understand the importance of this election."

Government officials have declared Friday a holiday to allow voters to cast their ballots. But in a nation with high levels of poverty and a wage of a $1.10 a day, most people continued work instead of voting.

Goods were carted in ox-drawn carts past the polling booths. Women at a river near a station did laundry, and local markets selling chicken and building materials remained open.

"Here in Madagascar, if you don't work, you don't eat," a resident said.

Madagascar, off Africa's east coast on the Indian Ocean, plunged into turmoil after current President Andry Rajoelina, a former disc jockey and mayor of the capital Antananarivo, seized power from ousted President Marc Ravalomanana with the help of the military in 2009.

Rajoelina told reporters after casting his vote in Antananarivo, that it was time Madagascar "returned to the constitutional order."

"The crisis has lasted too long...we feel the need of the Malagasy to fulfill their duty," he said.

Rajoelina allayed fears of a repeat of the 2009 coup saying "the results come from the choice of the people, we must accept it."

With 33 candidates running in the election, it could prove difficult for a clear winner to emerge in the first round. If none of the candidates garners more than 50 percent of the votes, the two top candidates will compete in a runoff scheduled for Dec. 20.

The two front-runners are backed by rivals Rajoelina and Ravalomanana. Former finance minister Hery Rajaonarimampianina has been endorsed by Rajoelina and medical doctor Robinson Jean Louis is Ravalomanana's candidate.

Nine candidates, including three key politicians, were barred from taking part in the polls as part of a plan to resolve the political crisis. Former presidents Rajoelina and Didier Ratsiraka and former president Ravalomanana's wife, Lalao, were excluded for failing to comply with the country's electoral laws.

The electoral body says more than 7.8 million eligible voters will cast their ballots at 20,000 polling stations.

Poverty is a serious problem in Madagascar. Half of the nation's children under five are severely malnourished and 1.5 million children are not in school, according to the U.N.

The coup resulted in the suspension of much-needed foreign aid. Madagascar was suspended from the African Union and the 15-nation Southern African Development Community, or SADC, until a constitutionally elected government was restored.

___

Associated Press photographer Schalk Van Zuydam in Antananarivo, Madagascar and writer Gillian Gotora in Johannesburg contributed to this report.

Source: http://news.yahoo.com/madagascar-holds-first-post-coup-vote-122105749.html
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Red Sox Take One-Game Lead In World Series


The Red Sox won the World Series opener in Boston on Wednesday night, beating the St. Louis Cardinals 8-1.



Copyright © 2013 NPR. For personal, noncommercial use only. See Terms of Use. For other uses, prior permission required.


RENEE MONTAGNE, HOST:


The Boston Red Sox have taken a one game to none lead over St. Louis in the World Series, beating the Cardinals eight to one last night at Fenway Park. The evening started off badly for the visitors and didn't improve from there. NPR's Mike Pesca was there and has this report.


MIKE PESCA, BYLINE: They call it the fall classic before anyone even has a chance to judge the quality of play. Last night the Cardinals put in a performance that was classically inept. Little Leaguers the world over are schooled in avoiding the incident that befell St. Louis to start off the second. Boston's Steven Drew popped the ball up between the pitcher's mound and home plate. Cardinal pitcher Adam Wainwright called for it, but grew passive as the ball arced downward.


Plop, right between catcher Yadier Molina and Wainwright. Fox's Joe Buck Had the call.


(SOUNDBITE OF GAME BROADCAST)


JOE BUCK: Jammed him on the mound. Adam Wainwright says everybody stay away. And it drops.


PESCA: It was a textbook error, but not a rulebook error, as a ball that a defender does not get a glove on is ruled a hit. This development was bad for two reasons. First, it was a precursor to a pair of Red Sox runs in the inning. But worse, it came after a first inning that was even more disastrous for St. Louis. Then, with two men on and one out, the powerful but slow David Ortiz came to bat.


Ortiz rocketed a textbook double play to second. But this game thwarted more textbooks than the state of Tennessee during the Scopes Monkey Trial. WEEI radio had the call.


(SOUNDBITE OF RADIO BROADCAST)


UNIDENTIFIED MAN: Here's the pitch. Swing and a chopper to the right side. Charged by Carpenter, flipped sideways to second. Dropped! Oh, they're going to say he's out on the exchange. John Farell's going to come out on this.


PESCA: This was a severely blown call. All the runners should have been safe. But when Boston manager John Farrell came out to make his case 38,345 screaming fans found they had a few allies in aggrievement. All five other umpires beside the one who made the original call indeed thought short stop Pete Kozma dropped the ball. After the game, Farrell acknowledged a reversal like that doesn't happen often.


(SOUNDBITE OF PRESS CONFERENCE)


JOHN FARRELL: I think based on their group conversation, surprisingly, to a certain extent, they overturned it and I think got the call right.


PESCA: Farrell argued that justice was served. But for the defense, because someone in a Cardinal uniform had to offer some version of defense, here's St. Louis manager Mike Matheny.


(SOUNDBITE OF PRESS CONFERENCE)


MIKE MATHENY: That's not a play I've ever seen before. And I'm pretty sure there were six umpires on the field that had never seen that play before either. And it's a pretty tough time to debut that overruled call in the World Series.


PESCA: Matheny was arguing process. Think about every time you've seen a manager jog onto a field to argue a call. Think about how often you see him jog off having won the argument. That's rare. And what if Farrell had stayed in the dugout? Would the umps have let the bad call stand? Unexplained. Boston's first baseman Mike Napoli acknowledged how unusual it all was.


(SOUNDBITE OF PRESS CONFERENCE)


MIKE NAPOLI: You rarely see that, you know, especially on a stage like this. But, you know, I think that was good for the game.


PESCA: It was good for Napoli, who came up with the bases loaded.


(SOUNDBITE OF CROWD CHEERING)


PESCA: And then soon stood on second with the bases empty. Three runs in the first, two in the second, a two-run homerun by David Ortiz - this was not close, especially with Boston pitcher Jon Lester mowing down Cardinals. Another setback for St. Louis in addition to the outcome occurred when their right fielder, Carlos Beltran, injured himself reaching over the outfield wall to rob David Ortiz of a home run.


Beltran left the game and was treated at a local hospital. The Cardinals indicate their clutch hitting outfielder could come back tomorrow. Baseball history suggests the Cardinals can too. They have Michael Wacha on the mound. The 22-year-old has three starts this postseason; he's won all three, having given up a total of one run. The Red Sox countered with John Lackey and Fenway Park. Mike Pesca, NPR News.


Copyright © 2013 NPR. All rights reserved. No quotes from the materials contained herein may be used in any media without attribution to NPR. This transcript is provided for personal, noncommercial use only, pursuant to our Terms of Use. Any other use requires NPR's prior permission. Visit our permissions page for further information.


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Source: http://www.npr.org/templates/story/story.php?storyId=240428488&ft=1&f=3
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Explosion at candy factory in Mexico kills one, injures dozens


By Julian Cardona

CIUDAD JUAREZ, Mexico (Reuters) - A boiler exploded at a candy factory in northern Mexico on Thursday, killing one person, injuring dozens and badly damaging the building, officials said.

They said at least one person was killed in the blaze at the factory which is located in an industrial park at Ciudad Juarez, a large city on the U.S. border.

"We're still searching the area to see if there are more dead," said Fernando Motta, head of the city's emergency services.

He said 11 people were badly injured, four of whom were in critical condition. Thirty people were treated for minor injuries, he said.

A second official, speaking on condition of anonymity, said around 20 people who work at the plant were unaccounted for. It was unclear if they were in the building at the time of the blast.

(Reporting by Julian Cardon, Dave Graham, Gabriel Stargardter and Luis Rojas; Editing by Sandra Maler and Mohammad Zargham)

Source: http://news.yahoo.com/explosion-candy-factory-north-mexico-kills-one-injures-012907366--finance.html
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Thursday, October 24, 2013

U.S. hog disease on the rise in No. 2 producer North Carolina


By Theopolis Waters


(Reuters) - After laying dormant during the hot summer weather, the onset of cooler fall temperatures has increased the spread of a virus lethal to young pigs in North Carolina, the second-biggest hog producer, a state agriculture official said.


The swine disease Porcine Epidemic Diarrhea Virus (PEDv) has spread to about 250 farms since June, Tom Ray, North Carolina director of livestock health, told Reuters on Thursday. While the disease continues to spread, Ray said it appears the rate of spread is slowing.


"We have about 250 positive swine farms," said Ray. "Probably about three of four weeks ago, we went from normally two to three cases in a week to three new reports in a day. That has actually started to go back to smaller numbers per week."


Ray said up to 150,000 sows could be affected. The disease is fatal to baby pigs, with the death rate in some litters up to 80 percent.


"It is definitely up," he said of the number of infected farms, however locating farms with the disease has been difficult because PEDv is a disease that is not required to be reported.


As of September 1, North Carolina had 8.7 million hogs, including a breeding herd of 870,000 head, according to the U.S. Department of Agriculture.


PEDv is not harmful to humans nor is it transmissible through pork. It has occurred in Europe and Asia, but this is the first year that it has been seen in the United States.


"You have a (hog) population that is naive because it has never been exposed to this disease before," said Ray. "Not having this virus before, you are going to have more losses initially."


"We're really holding our collective breaths because the virus has a tendency to peak in cooler weather in the winter," he said.


"It is definitely on the rise, but so is the immunity," he said of the number of cases. "But we had a slower rise in the last week or so than about two to three weeks ago."


The death of baby pigs from the disease will mean fewer market hogs next spring.


Heather Jones, senior agribusiness analyst at BBT Capital markets, estimates losses in North Carolina from the disease could cut weekly hog slaughter next spring by 1 to 1.5 percent.


Longer-term pig losses from the disease should decrease as herds become immune to it and the pork industry develops vaccines to cope with it, said Ray.


"Eventually it is going to be the new-normal production disease," he added.


(Additional reporting by Bob Burgdorfer; Editing by Eric Walsh)

Source: http://news.yahoo.com/u-hog-disease-rise-no-2-producer-north-205529901.html
Category: seahawks   Henry Blackaby   nbc   "i Have A Dream" Speech   taylor swift  

Symphonies Show Their Brass In World Series Smackdown Video


Talking smack is practically a right of passage for baseball fans. As the St. Louis Cardinals face off against the Boston Red Sox in the World Series this week, members of the two cities' symphonies — the brass sections, to be exact — took their rivalry to YouTube with a video smackdown.


Source: http://www.npr.org/templates/story/story.php?storyId=240559696&ft=1&f=1055
Category: apple   Josh Freeman   constitution day   Nothing Was The Same Leak   NSYNC VMA 2013  

Rodríguez On World Cafe





Linus Hallsénius/Courtesy of the artist


Rodríguez.


Linus Hallsénius/Courtesy of the artist





  • "Crucify Your Mind"

  • "This Is Not a Song, It's an Outburst: Or, the Establishment Blues"



For another dose of Sense of Place: Detroit, we revisit an archived studio session from 2009 Rodríguez. The Motor City folk rocker's albums from the '70s, Cold Fact and Coming from Reality, were being re-released at the time of this interview. While those records became huge hits in South Africa several years after their initial U.S. release, back in Detroit, Rodriguez was completely unaware of his fame until decades later.


The incredible story of Rodríguez's latent success was brought to an international audience by the 2012 documentary Searching for Sugar Man. He tells the tale in his own words here on the World Cafe.


Source: http://www.npr.org/blogs/WorldCafe/2013/10/24/240552394/rodr-guez-on-world-cafe?ft=1&f=10001
Tags: homeland   aldon smith   Bill De Blasio   Romain Dauriac   the bachelorette  

Irish High Court to review Facebook Prism complaint





The Irish High Court is going to review whether the Irish Data Protection Commissioner's refusal to investigate Facebook's involvement with the U.S. government surveillance program Prism was lawful.


In June, the Austrian student group Europe-v-Facebook filed a complaint with the Irish DPC against Facebook Ireland, which is responsible for the data of the company's users outside the U.S. and Canada. When Facebook collects user data, exports it to the U.S. and by doing this giving the National Security Agency (NSA) the opportunity to use it for massive surveillance of personal information without probable cause, Facebook is violating European privacy laws, according to the group.


The Irish DPC however argued that there were no grounds to start an investigation under the Irish Data Protection Act because "safe harbor" requirements have been met.


Europe-v-Facebook maintained that the Irish privacy regulator should start an investigation and applied for a judicial review of this refusal with the Irish High Court in late August. The High Court decided to start such a review on Monday, according to a court document that was published by Europe-v-Facebook on Thursday.


In Ireland, a judicial review can be used to supervise lower courts, tribunals and other administrative bodies to ensure that they make their decisions properly and in accordance with the law. If such a decision was unconstitutional or illegal the High Court can choose to quash the decision.


If Europe-v-Facebook's complaint is successful, Facebook could eventually "be forced to limit the access of the NSA to Europeans' data or would otherwise need to keep Europeans' data within the E.U.," the group said in a news release.


Europe-v-Facebook filed a similar complaint against Apple in Ireland which was denied on the same grounds. Currently, the group is only pursuing the case against Facebook in Ireland.


While the Irish privacy regulator appears reluctant to investigate Facebook and Apple, other European privacy regulators did start investigations on the basis of similar complaints filed by Europe-v-Facebook and others.


The Luxembourg data protection authority, for instance, is investigating Microsoft-owned Skype for its alleged links to the Prism spying program. It will probably publish its findings before the end of next week, said a spokesman for the authority.


Meanwhile, Yahoo is under investigation by the German Federal Commissioner for Data Protection and Freedom of Information, said Juliane Heinrich, a spokeswoman for the Commissioner, in an email on Tuesday. "Yahoo has submitted a first statement that raised further questions," she said, adding that she could not share Yahoo's statement or give more detailed information during the examination phase. She expects the investigation to be finished in December.


Loek is Amsterdam Correspondent and covers online privacy, intellectual property, open-source and online payment issues for the IDG News Service. Follow him on Twitter at @loekessers or email tips and comments to loek_essers@idg.com




Loek Essers, IDG News Service Amsterdam correspondent for IDG News Service, IDG News Service


Loek Essers focuses on online privacy, intellectual property, open-source and online payment issues.
More by Loek Essers, IDG News Service












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Source: http://www.pcworld.com/article/2057640/irish-high-court-to-review-facebook-prism-complaint.html#tk.rss_all
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'X-Men: Days Of Future Past': Watch The Sneak Peek Of The Trailer Now!


The first seven seconds of footage from the movie has leaked online.


By Alex Zalben








Source:
http://www.mtv.com/news/articles/1716123/x-men-days-of-future-past-teaser-trailer.jhtml

Tags: Jeff Soffer   Helen Lasichanh   alice eve   megyn kelly   The Wolverine  

8.1 features Microsoft removed from Windows 8.1






Forget about the desktop improvements and Bing Smart Search: Windows 8.1’s biggest draw may be the sheer volume of new and hidden features. Seriously—it’s jam-packed.


But apparently Microsoft needed to clear room for all the fresh ideas. Windows 8.1 shaves away many of Windows 8’s auxiliary features. Some of the removals are blatant once they’re pointed out, while others are more obscure, but all are off the table in Windows 8.1.


1. Messaging app


We’ll miss you, buddy. Maybe.

Windows 8’s IM capabilities were handled by the aptly named Messaging, one of the core apps shining front and center on the live-tiled Start screen. No more: Microsoft has kicked Messaging to the curb less than a year after the app’s arrival, replacing the Windows 8 native with Skype.


As high-profile as the swap is, it’s no great loss. Messaging was pretty lackluster and largely overlapped Skype’s core functionality. Meanwhile, Skype’s communication services are also being baked into the Xbox One and Outlook.com (but not Windows Phone). One bummer: Messaging supported Facebook Chat, while Skype does not.


2. Windows Experience Index



Ever since the Vista days, Windows provided a “Windows Experience Index” score in your My Computer properties. The WEI score was supposed to be a numerical indicator of your PC’s brawn. Powerful PCs received higher scores, and so on.


Unfortunately, the WEI’s scoring criteria weren’t well known, and it placed odd, seemingly artificial caps on the highest possible scores. (Windows 7’s cap was 7.9, while Vista’s was 5.9.) Whether for these or other reasons, the WEI never seemed to catch on, and it’s nowhere to be found in Windows 8.1.


3. Facebook and Flickr in the Photos app


Windows 8’s gorgeous Photos app. Note the Facebook and Flickr integration. (Click to enlarge.)

Regrettably, Windows 8.1’s Photos app no longer supports Facebook and Flickr image integration.


“In Windows 8, we wanted to provide a way for folks to view their photos on other services, knowing there would be few (if any) apps in the store at launch that would do so,” a Microsoft representative said. “Now there are many apps in the store that offer ways to view photos on other services.”


Windows 8.1’s Photos app is far more lackluster in both aesthetics and capabilities. (Click to enlarge.)

A Facebook app launched in the Windows Store the same day as Windows 8.1, but its image-management and sharing capabilities aren’t as flexible as those in Windows 8’s Photos app. And despite Flickr’s sudden disappearance from the Photos app, an official app for that service has yet to appear in the Windows Store.


4. Libraries?


Your Documents, Music, Pictures, and Videos libraries aren’t visible by default in Windows 8.1—but that doesn’t mean they’re not there. Activating them is easy, as shown in the single screenshot below.


Click View > Navigation Pane > Show Libraries in the desktop file explorer. Boom! Done.

Some websites are reporting, though, that Windows 8.1’s libraries ditch Public folders. Our experiences are a bit more hit-and-miss: Public folders appeared in my Windows 8.1 libraries after I upgraded from Windows 8, but they were a no-show in the libraries of another PCWorld editor.


Don’t let that bring you down! After reenabling libraries using the method outlined above, just right-click a library and select Properties > Add… to toss additional folders into the mix.


5. Windows 7 File Recovery, kind of


Ominous portents swirled when the Windows 8.1 Preview pushed out without the ‘Windows 7 File Recovery’ image-backup option found in Windows 8, especially since Microsoft has clearly stated that the tool is being deprecated in favor of Windows 8’s File History. And yes, it’s still missing in Windows 8.1.


A system image utility by any other name...

But fear not! Though Windows 7 File Recovery is dead in name, it lives on in spirit as ‘System Image Backup’. Just head to Control Panel > System & Security > File History, and then look in the lower-left corner.


6. Apps splashed on the Start screen


In Windows 8, all newly installed apps and desktop programs automatically received a tile on the modern Start screen. That isn’t the case in Windows 8.1: Now, you have to dive into the All Apps screen and manually pin new software to the Start screen.


A Start screen cluttered by Windows 8’s default tile creation. The feature will not be missed in Windows 8.1—at least not by me.

That’s a big win in my book, since installing desktop programs often plopped tiles for dozens of auxiliary executables, languages, and other options on the Start screen alongside the link to the base program, resulting in a distressing amount of clutter. Less-seasoned computer users may become confused when installed apps fail to appear on the Start screen by default, however—especially since the returned Start button’s behavior trains you to consider the Start screen as a “modern”-day Start-menu replacement. Steel yourself for the support calls from family and friends.


7. My Computer



Yes, the nearly 20-year-old ‘My Computer’ moniker has retired, giving way to the more cloud- and cross-platform-friendly ‘This PC’. Desktop fallout from the focus on “One Microsoft” continues—though this is an admittedly trivial change.


8. SkyDrive desktop program


Keen-eyed SkyDrive users will note that jumping to Windows 8.1 erases the discrete (and optional) SkyDrive desktop software that served to keep local files in sync with the cloud. And that makes sense: Microsoft’s cloud service weaves itself tightly into Windows 8.1, and the desktop program’s functionality has largely been replaced by the update’s native SkyDrive support.


8.1. SkyDrive desktop-program functionality


Continuing with that theme, some of the more obscure yet helpful functions of the SkyDrive desktop program haven’t been replicated by Windows 8.1’s native features. For one thing, upgrading to Windows 8.1 kills SkyDrive’s remote Fetch feature.


Also be aware that unlike the desktop program, SkyDrive in Windows 8.1 relies on symbolic links to point to cloud-stored files in File Explorer, even though everything appears to be saved locally at first glance. This “smart files” functionality can save a lot of space on tablets and other storage-restricted devices, but if you’d like to keep local copies of your stuff, right-click the SkyDrive icon in File Explorer and select Make available offline.


Your SkyDrive-stored files aren’t fully saved locally by default in Windows 8.1. Here’s how to fix that.

You can also right-click individual files and folders and choose to make them online-only or available offline.


Still worth the upgrade


Don’t let these little omissions dissuade you: Windows 8.1 is superior to Windows 8 in virtually every way. It represents a much less jarring version of Microsoft’s grand vision of a cross-platform future—though it still won’t win over folks whose lips instinctively curl at the merest mention of the word “Metro.” Check out PCWorld’s definitive review of Windows 8.1 for all the juicy details. (And if you’re one of those desktop diehards, you might want to check out our guide to banishing the modern UI from your Windows 8.1 PC.)











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Source: http://www.pcworld.com/article/2057222/8-1-features-microsoft-removed-from-windows-8-1.html#tk.rss_all
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'Carrie,' Cumberbatch, Schwarzenegger Feel The Weight Of 'Gravity'


'12 Years a Slave' is off to strong art-house start as 'Gravity' sinks all wide releases.


By Ryan J. Downey








Source:
http://www.mtv.com/news/articles/1715881/carrie-escape-plan-movie-box-office.jhtml

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U.S. energy-related carbon pollution at lowest since 1994


WASHINGTON (Reuters) - Carbon dioxide emissions from energy production in the United States fell to 5.29 billion metric tons in 2012 - its lowest level since 1994 - despite a growing economy and rising population, according to government data released on Monday.


The Energy Information Administration, the statistics arm of the Department of Energy, said there was a 3.8 percent drop from the previous year.


That marked the largest decline in a non-recession year since EIA started tracking the data.


The latest decline came amid a large drop in energy intensity, the amount of energy consumed relative to GDP.


"The emissions decline was the largest in a year with positive growth in per capita output and the only year to show a decline where per capita output increased 2 percent or more," the EIA said.


Energy consumption fell 2.4 percent in 2012 from 2011 while GDP rose 2.8 percent.


In addition to reduced energy intensity, carbon dioxide emissions reflected lower residential sector demand for heating after a warmer-than-usual winter in 2012.


(Reporting by Valerie Volcovici; Editing by Ros Krasny and Leslie Gevirtz)

Source: http://news.yahoo.com/u-energy-related-carbon-pollution-lowest-since-1994-222309024.html
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A Toddler Remains HIV-Free, Raising Hope For Babies Worldwide





HIV-positive babies rest in an orphanage in Nairobi, Kenya. Treatment right after birth may make it possible for HIV-positive newborns to fight off the virus.



Brent Stirton/Getty Images


HIV-positive babies rest in an orphanage in Nairobi, Kenya. Treatment right after birth may make it possible for HIV-positive newborns to fight off the virus.


Brent Stirton/Getty Images


A 3-year-old girl born in Mississippi with HIV acquired from her mother during pregnancy remains free of detectable virus at least 18 months after she stopped taking antiviral pills.


New results on this child, published online by the New England Journal of Medicine, appear to green-light a study in the advanced planning stages in which researchers around the world will try to replicate her successful treatment in other infected newborns.


And it means that the Mississippi girl still can be considered possibly or even probably cured of HIV infection — only the second person in the world with that lucky distinction. The first is Timothy Ray Brown, a 47-year-old American man apparently cured by a bone marrow transplant he received in Berlin a half-dozen years ago.


This new report addresses many of the questions raised earlier this year when disclosure of the Mississippi child's case was called a possible game-changer in the long search for an HIV cure.


"There was some very healthy skepticism," Dr. Katherine Luzuriaga, a professor at the University of Massachusetts in Worcester, tells Shots. She's part of the team that has been exhaustively testing the toddler's blood and considering every possible explanation for her apparently HIV-free state.


Luzuriaga is confident the latest tests prove that the child was truly infected with HIV at the time of her birth — not merely carrying remnants of free-floating virus or infected blood cells transferred before birth from her mother, as some skeptics wondered.



The UMass researcher says there's no way the child's mother could have contributed enough of her own blood plasma to the newborn to account for the high levels of HIV detected in the child's blood shortly after birth.


Similarly, Luzuriaga says, new calculations show that the mother "would have had to transfer a huge number of [HIV-infected] white blood cells to the baby in order for us to get the [viral] signal that we got early on."


Clinching the question as far as the researchers are concerned is the infant's response to anti-HIV drugs that she began receiving shortly after birth. The remarkable earliness of her treatment is a crucial feature that makes this child different from almost any other.


"There's a very characteristic clearance curve of viruses once we start babies on treatment," Luzuriaga says. "The decay of viruses we see in this baby is exactly what we saw in early treatment trials from 20 years ago when we initiated anti-retroviral therapy and shut off viral replication. That's a very different decay curve than you would expect if it were just free virus transferred to the baby."


It might be helpful to recap the unusual, if not unique, features of the Mississippi case.


Her mother did not receive prenatal care, so she was not identified as HIV-infected before delivery. If she had been, she would have received drugs that are highly effective in preventing mother-to-child transmission of the virus.


While the mother was in labor, she got HIV testing, as is routine for women without prenatal care. When that came up positive, Dr. Hannah Gay, a pediatrician at the University of Mississippi Medical Center in Jackson, was ready to test the newborn for infection and start anti-retroviral medicines within 30 hours of birth.


The treatment quickly cleared the virus from the baby's blood. Normally such children would stay on antiviral drugs for a lifetime. But in this case the mother – whose life circumstances were reportedly chaotic – stopped giving the child the medication between 15 and 18 months after birth.


Gay and her colleagues caught up to the child when she was 23 months old and were astonished to discover she was apparently still virus-free despite being off treatment. Five rounds of state-of-the-art testing — at UMass, Johns Hopkins, federal research labs and the University of California San Diego — failed to reveal any trace of the virus in her blood.


That led to last spring's report and widely reported hope that the child had been cured of HIV.


But Dr. Scott Hammer, an HIV researcher at Columbia University in New York, is not quite convinced. "Is the child cured of HIV infection? The best answer at this moment is a definitive 'maybe,' " Hammer writes in a New England Journal editorial that accompanied the report.


The reason is that a couple of tests done when the child was about 2 years old found indications that her system may contain pieces of RNA or DNA from HIV. This hints that some of the nucleic acid building blocks of the virus are hanging around within her blood cells.


There's no evidence these "proviral" remnants are capable of assembling themselves into whole viruses that can make copies of themselves. But researchers are concerned about that possibility and how it might be headed off.


"The question is whether those viral nucleic acids have the ability at some point to replicate and allow a rebound of the virus," Luzuriaga acknowledges. "That's why it's important to continue to test the baby over time." She says that means years.


But for now, the signs from the Mississippi child's case are encouraging enough to have generated an ambitious global human experiment that Luzuriaga says is in final planning stages.


Women who present in labor without having had prenatal care will be tested for HIV and, if positive, their infants will be intensively treated within a couple of days of birth, as the Mississippi child was. Then they'll be followed with the most sensitive tests to determine if the virus has been eradicated.


If certain criteria are met, researchers plan to decide whether it would be safe to discontinue HIV treatment deliberately and follow the children closely to see if the virus returns. (If it did, treatment would be restarted.)


If the experiment succeeds, it would be a huge advance in the prevention of childhood HIV and AIDS in many parts of the world. More than 9 out of 10 of the world's 3.4 million HIV-infected children live in sub-Saharan Africa, where many women deliver without having had prenatal care or HIV treatment. Around 900 children are newly infected every day.


Meanwhile, researchers pursuing an HIV cure will convene next month in San Francisco to consider various strategies — for adults as well as children. One other recent glimmer of hope was provided this summer by Boston researchers who reported that two HIV-infected men with lymphoma remain virus-free without treatment for several months after stopping antiviral treatment.


Source: http://www.npr.org/blogs/health/2013/10/23/240272831/a-toddler-remains-hiv-free-raising-hope-for-babies-worldwide?ft=1&f=1003
Category: chicago bears   scarlett johansson   LC Greenwood   9/11   dave chappelle  

CNIO researchers discover new genetic errors that could cause 1 of the most deadly leukaemias

CNIO researchers discover new genetic errors that could cause 1 of the most deadly leukaemias


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23-Oct-2013



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Contact: Nuria Noriega
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Centro Nacional de Investigaciones Oncologicas (CNIO)



The sequencing of the acute dendritic cell leukaemia exome shows that more than half of patients display 'epigenetic' gene alterations



Acute dendritic leukaemia is a rare type of leukaemia, but one with the worst prognosisthe average patient survival rate is just 12-14 monthsthat is difficult to treat. Juan Cruz Cigudosa's team, from the Spanish National Cancer Research Centre's (CNIO) Molecular Cytogenetics Group, has for the first time sequenced the exome the coding, or protein-generating, regions of the genome of dendritic cell leukaemia.


The analyses, published in Leukemia, the world's leading journal in onco- haematology, uncover new genetic pathways that could revolutionise treatment guidelines for these patients.


'EPIGENETIC' GENES ARE ALTERED IN MOST CASES


For the first time in human leukaemias, scientists have described mutations in four genes (IKZF3, HOXB9, UBE2G2 and ZEB2) that have important cellular functions, such as gene regulation and cellular differentiation.


"In addition to these genes, we have found that more than half of the cases harbour mutations in epigenetic genes at diagnosis those genes that introduce chemical modifications in the DNA something that had never been observed in this type of leukaemia", says Cigudosa. "Therapies
directed against these epigenetic genes already exist, so these patients could also benefit from them".


In summary, the genetic profile of acute dendritic cell leukaemia, currently treated as a lymphoid leukaemia, is similar to that of myeloid leukaemia. "These results suggests a change in the treatment guidelines for these patients, who were completely misplaced", says Juliane Menezes, the first author of the study.


According to Cigudosa, "this study is a clear example of the role of genomics in translational research being carried out by Spanish scientists, in general, and more specifically at CNIO".


To carry out this work, the authors analysed the exome of three patients diagnosed with dendritic cell leukaemia and validated the results using a panel of 38 genes and 25 additional patients (known as a targeted resequencing strategy), coming from 9 Spanish hospitals.


###


This research was conducted in collaboration with CNIO's Bioinformatics Core Unit, led by David Pisano, the Pathology Services at the Marques de Valdecilla Hospital in Santander, led by Miguel Angel Piris, as well as several Spanish Genetics and Haematology Services.


Acknowledgements: the study has been supported by the Ministry of Economy and Competitiveness, the Carlos III Health Institute, the Spanish Association Against Cancer (AECC) and 'La Caixa' Foundation.


Reference article:

Exome sequencing reveals novel and recurrent mutations with clinical impact in blastic plasmacytoid dendritic cell neoplasm. Menezes J, Acquadro F, Wiseman M, Gómez-López G, Salgado RN, Talavera-Casañas JG, Buño I, Cervera JV, Montes-Moreno S, Hernández-Rivas JM, Ayala R, Calasanz MJ, Larrayoz MJ, Florensa L, Gonzalez-Vicent M, Pisano DG, Piris MA, Alvarez S, Cigudosa JC. Leukemia (2013). DOI: 10.1038/leu.2013.283




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CNIO researchers discover new genetic errors that could cause 1 of the most deadly leukaemias


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

23-Oct-2013



[


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]


Share Share

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)



The sequencing of the acute dendritic cell leukaemia exome shows that more than half of patients display 'epigenetic' gene alterations



Acute dendritic leukaemia is a rare type of leukaemia, but one with the worst prognosisthe average patient survival rate is just 12-14 monthsthat is difficult to treat. Juan Cruz Cigudosa's team, from the Spanish National Cancer Research Centre's (CNIO) Molecular Cytogenetics Group, has for the first time sequenced the exome the coding, or protein-generating, regions of the genome of dendritic cell leukaemia.


The analyses, published in Leukemia, the world's leading journal in onco- haematology, uncover new genetic pathways that could revolutionise treatment guidelines for these patients.


'EPIGENETIC' GENES ARE ALTERED IN MOST CASES


For the first time in human leukaemias, scientists have described mutations in four genes (IKZF3, HOXB9, UBE2G2 and ZEB2) that have important cellular functions, such as gene regulation and cellular differentiation.


"In addition to these genes, we have found that more than half of the cases harbour mutations in epigenetic genes at diagnosis those genes that introduce chemical modifications in the DNA something that had never been observed in this type of leukaemia", says Cigudosa. "Therapies
directed against these epigenetic genes already exist, so these patients could also benefit from them".


In summary, the genetic profile of acute dendritic cell leukaemia, currently treated as a lymphoid leukaemia, is similar to that of myeloid leukaemia. "These results suggests a change in the treatment guidelines for these patients, who were completely misplaced", says Juliane Menezes, the first author of the study.


According to Cigudosa, "this study is a clear example of the role of genomics in translational research being carried out by Spanish scientists, in general, and more specifically at CNIO".


To carry out this work, the authors analysed the exome of three patients diagnosed with dendritic cell leukaemia and validated the results using a panel of 38 genes and 25 additional patients (known as a targeted resequencing strategy), coming from 9 Spanish hospitals.


###


This research was conducted in collaboration with CNIO's Bioinformatics Core Unit, led by David Pisano, the Pathology Services at the Marques de Valdecilla Hospital in Santander, led by Miguel Angel Piris, as well as several Spanish Genetics and Haematology Services.


Acknowledgements: the study has been supported by the Ministry of Economy and Competitiveness, the Carlos III Health Institute, the Spanish Association Against Cancer (AECC) and 'La Caixa' Foundation.


Reference article:

Exome sequencing reveals novel and recurrent mutations with clinical impact in blastic plasmacytoid dendritic cell neoplasm. Menezes J, Acquadro F, Wiseman M, Gómez-López G, Salgado RN, Talavera-Casañas JG, Buño I, Cervera JV, Montes-Moreno S, Hernández-Rivas JM, Ayala R, Calasanz MJ, Larrayoz MJ, Florensa L, Gonzalez-Vicent M, Pisano DG, Piris MA, Alvarez S, Cigudosa JC. Leukemia (2013). DOI: 10.1038/leu.2013.283




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Source: http://www.eurekalert.org/pub_releases/2013-10/cndi-crd102313.php
Tags: Pretty Little Liars   Valerie Harper   Dreamchasers 3   september 11   diana nyad